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It is our goal to provide you with support, encouragement, and the appropriate tools and information to help you manage the many aspects of your treatment

Frequently Asked Questions

What is ISTURISA?

ISTURISA (is tur ee’ sah) is a prescription medicine used to treat adult patients with Cushing’s disease who can’t have pituitary surgery, or who have had pituitary surgery but were not cured of their Cushing’s disease.1

What is Cushing’s disease?

Cushing’s disease is a rare hormonal condition caused when a noncancerous tumor on the pituitary gland produces too much of a natural hormone called adrenocorticotropic hormone (ACTH). The extra ACTH then leads to overproduction of another natural hormone called cortisol. The overproduction of cortisol causes the symptoms of Cushing’s disease.2

What is the difference between Cushing’s disease and Cushing’s syndrome?

In addition to Cushing’s disease, you may also have heard of Cushing’s syndrome. They are not the same thing. Cushing’s disease is the most common form of Cushing’s syndrome. Cushing’s syndrome is actually a set of related symptoms caused by too much cortisol circulating in the body from sources other than the pituitary gland. Cushing’s disease is the name used when the Cushing’s symptoms are caused by a pituitary tumor (a kind of tumor that causes oversecretion of ACTH that leads to excess cortisol levels).

What is the primary treatment goal in Cushing’s disease?

The primary treatment goal for patients with Cushing’s disease is to bring your body’s cortisol levels back to normal.2,3

Why is ISTURISA different?

ISTURISA is an FDA-approved tablet you take twice a day to help reduce the amount of cortisol produced by the adrenal glands. ISTURISA is for adult patients with Cushing’s disease who can’t have pituitary surgery, or who have had pituitary surgery but were not cured of their Cushing’s disease.1

With ISTURISA, you can look forward to1:

  • A proven treatment for Cushing’s disease that can help you reach and maintain normal cortisol levels
  • Tablets that can be taken with or without food
  • Dosing that can be personalized
  • A fully-dedicated team to support you during your treatment

How do I know if ISTURISA is working?

The best way to know if ISTURISA is working for you is to talk to your doctor about how you’re feeling and any changes in your activity level since starting ISTURISA. Your doctor will use this information to help optimize your treatment plan.

What are the most common side effects associated with ISTURISA?

The most common side effects experienced by patients in the clinical study of ISTURISA included1:

  • Very low cortisol levels (hypocortisolism)
  • Tiredness (fatigue)
  • Nausea
  • Headache
  • Swelling of the legs, ankles, or other signs of fluid retention (edema)

If you experience side effects, please contact your doctor right away.

When ISTURISA is working to bring your cortisol levels down, you could experience symptoms of cortisol withdrawal. These include flu-like symptoms, such as1:

  • Nausea
  • Vomiting
  • Tiredness (fatigue)
  • Low blood pressure
  • Stomach (abdominal) pain
  • Loss of appetite
  • Dizziness

If you experience more than one of the symptoms above, tell your doctor right away. They may indicate very low cortisol levels (hypocortisolism).

How do I know if my insurance will pay for ISTURISA?

The R.A.R.E. patient support program is designed to make it easier for you to access and stay on your treatment. With R.A.R.E., Insurance Specialists will support you in obtaining insurance coverage for your medication, and to help you stay up to date with any changes in your medication coverage.

R.A.R.E. can help commercially-insured patients get their medication for no more than $20 per month.*

For patients who are not eligible for copay support or who need additional financial assistance, R.A.R.E. can help connect you with alternative forms of medication coverage, or provide referrals to other possible sources of funding.*

Patient Assistance Program - Patients who lack insurance and meet certain financial requirements may be eligible for additional financial support from a Patient Assistance Program.*

*Restrictions, limitations, and/or eligibility requirements apply.

What support is available to help me meet my treatment goals with ISTURISA?

Shortly after beginning treatment, a specially trained R.A.R.E. Nurse Ambassador will call you to ensure your treatment is off to a good start, answer questions about your condition or medication, and discuss your treatment goals. You can also look forward to regular phone calls from your R.A.R.E. Nurse Ambassador.

What if I have questions about my ISTURISA prescription, medication deliveries, or refills?

To help you stay on track with your treatment, the specialty pharmacy will remain in contact with you regarding medication refills and deliveries. You can also speak to a clinical pharmacist over the phone 24 hours a day, 7 days a week by calling 1-888-855-RARE (7273).

Helpful Links

The following websites can provide you with more information about Cushing’s disease.

ISTURISA® (osilodrostat) Important Safety Information

Indications and Usage

ISTURISA (osilodrostat) is used to treat adults with Cushing’s disease who cannot have pituitary surgery, or who have had pituitary surgery, but the surgery did not cure their Cushing’s disease.

Important Safety Information:

  • Hypocortisolism: Treatment with ISTURISA may cause symptoms associated with low levels of cortisol in your blood (hypocortisolism). Tell your healthcare provider right away if you experience more than one of the following symptoms, as these may be symptoms of very low cortisol level, known as adrenal insufficiency: nausea, vomiting, tiredness (fatigue), low blood pressure, stomach (abdominal) pain, loss of appetite, dizziness. If you get symptoms of hypocortisolism while taking ISTURISA, your healthcare provider may change your dose or ask you to stop taking it.

ISTURISA® (osilodrostat) Important Safety Information

Indications and Usage

ISTURISA (osilodrostat) is used to treat adults with Cushing’s disease who cannot have pituitary surgery, or who have had pituitary surgery, but the surgery did not cure their Cushing’s disease.

Important Safety Information:

  • Hypocortisolism: Treatment with ISTURISA may cause symptoms associated with low levels of cortisol in your blood (hypocortisolism). Tell your healthcare provider right away if you experience more than one of the following symptoms, as these may be symptoms of very low cortisol level, known as adrenal insufficiency: nausea, vomiting, tiredness (fatigue), low blood pressure, stomach (abdominal) pain, loss of appetite, dizziness. If you get symptoms of hypocortisolism while taking ISTURISA, your healthcare provider may change your dose or ask you to stop taking it.
  • Heart Problem or Heart Rhythm Problem: ISTURISA may cause an irregular heartbeat which could be a sign of a heart problem called QT prolongation. Call your healthcare provider right away if you have irregular heartbeats.
  • Increase in Other Adrenal Hormone Levels: Your other adrenal hormones may increase when you take ISTURISA. Your healthcare provider may monitor you for the symptoms associated with these hormonal changes while you are taking ISTURISA such as low potassium (hypokalemia), high blood pressure (hypertension), swelling (edema) in the legs, ankles, or other signs of fluid retention, excessive facial or body hair growth (hirsutism), acne (in women). Call your healthcare provider if you have any of these side effects.
  • Most common side effects include very low cortisol levels (adrenal insufficiency), tiredness (fatigue), nausea, headache, swelling of the legs, ankles or other signs of fluid retention (edema). These are not all of the possible side effects of ISTURISA.

To report SUSPECTED SIDE EFFECTS, contact Recordati Rare Diseases Inc. at 1-888-575-8344, or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before taking ISTURISA, tell your doctor about all of your medical conditions, including if you:

  • have or had heart problems, such as an irregular heartbeat, including a condition called prolonged QT syndrome (QT internal prolongation). Your healthcare provider will check the electrical signal of your heart (called an electrocardiogram) before you start taking ISTURISA, 1 week after starting ISTURISA, and as needed after that.
  • have a history of low levels of potassium or magnesium in your blood.
  • have liver problems.
  • are breastfeeding or plan to breastfeed. It is not known if ISTURISA passes into your breast milk. You should not breastfeed if you take ISTURISA and for 1 week after stopping treatment.

Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines used to treat certain heart problems. Ask your healthcare provider if you are not sure whether your medicine is used to treat heart problems.

Please see the accompanying Full Prescribing Information, including the Medication Guide, for ISTURISA and talk with your healthcare provider.

Reference: 1. ISTURISA® (osilodrostat) [full prescribing information]. Lebanon, NJ: Recordati; March 2020. 2. Pivonello R, De Martino MC, De Leo M, Simeoli C, Colao A. Cushing’s disease: the burden of illness. Endocrine. 2017;56(1):10-18. 3. Nieman LK, Biller BM, Findling JW, et al. Treatment of Cushing’s Syndrome: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015;100(8):2807-2831.